Esthesioneuroblastoma grading sheet

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Jan 02, 2018 · Esthesioneuroblastoma (ENB), also known as olfactory neuroblastoma, is a rare neoplasm originating from olfactory neuroepithelium. Due to the rare and complex nature of ENB, multiple opinions exist regarding the etiology, optimal staging system, and treatment modalities.
Esthesioneuroblastoma has various clinical behaviors. Tumor stage by itself has little effect on long-term prognosis, especially if gross tumor removal is accomplished. Tumor grade is the most important factor in determining prognosis for tumor recurrence and survival. I was diagnosed with esthesioneuroblastoma on August 20th...a complete shocker after thinking I was going to receive a clean bill of health following sinus surgery to remove a "polyp" (I was later told that he removed 90% of the tumor). My local doctor referred me to Dr. Alexander Chiu at the Hospital at the University of Pennsylvania.

Object: Esthesioneuroblastoma (ENB) is a rare malignant neuroendocrine tumor originating from the olfactory neuroepithelium in the cribriform plate. Controversy still exists regarding the role of pathologic grading (Hyams grade) in prognostication.
esthesioneuroblastoma: ( es-thē'zē-ō-nū'ō-blas-tō'mă ), A neoplasm of immature, poorly differentiated neuronal cells believed to arise from neuroepithelial precursors. [esthesio- + neuroblastoma]

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Esthesioneuroblastoma (es-thee-zee-o-noo-row-blas-TOE-muh) is a rare type of cancer that begins in the upper portion of the nasal cavity. The area where esthesioneuroblastoma begins is separated from the brain by a bone that contains tiny holes that allow the nerves that control smell (olfactory nerves) to pass through.
Staging esthesioneuroblastoma Esthesioneuroblastoma is a rare cancer that starts in the nervous system cells responsible for smell. The most common staging system for esthesioneuroblastoma is the Kadish staging system. Esthesioneuroblastoma is a disease in which malignant (cancer) cells form in the tissues of the upper nasal cavity and base of the skull. Signs and symptoms of esthesioneuroblastoma include nosebleeds and the loss of sense of smell. Tests that examine the nasal cavity are used to help detect (find ... ENB, also known as olfactory neuroblastoma, is a malignant neoplasm of neuroectodermal origin. It is believed to arise from the olfactory epithelium lining the upper third of the nasal septum, the cribriform plates, and the superior turbinates. 1 First described by Berger et al in 1924, 2 ENB is a rare tumor, accounting for only 3%–6% of intranasal cancers. 3,4 As such, much about its ...